Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross-Sectional Analysis From the VOLTAIRE Study.
Ruofei Trophy Chen, Adam J Nelson, Sophia Zoungas et al.
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In 30 seconds
This cross-sectional analysis from the VOLTAIRE study evaluated cardiovascular risk profiles in 126 adults with type 2 diabetes using computed tomography coronary angiography and polygenic risk scores. The study found that 40.5% of participants had moderate-to-severe coronary stenosis, highlighting significant heterogeneity in atherosclerotic burden and limited concordance among clinical, anatomical, and genetic risk assessments.
Key findings
- 34.9% of participants had a coronary artery calcium (CAC) score of 0.
- 40.5% exhibited moderate-to-severe coronary stenosis (≥ 50%).
- Only 8.7% were classified as high risk across clinical, anatomical, and genetic domains.
Why it matters
Understanding the heterogeneity in cardiovascular risk profiles among patients with type 2 diabetes is crucial for tailoring prevention strategies. This study emphasizes the need for a comprehensive approach that integrates various risk assessment methods.