Premeal insulin administration lowers postprandial blood glucose and increases myocardial microvascular blood flow in people with type 1 diabetes: a randomised, crossover clinical trial.
DiabetologiaJul 11, 2026 (epub)
William B Horton, Kara C Anderson, Kaitlin M Love et al.
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In 30 seconds
This randomized crossover trial evaluated the effects of premeal versus postmeal insulin administration on vascular function in 18 young adults with type 1 diabetes. Results showed that premeal insulin significantly reduced postprandial glucose levels and increased myocardial microvascular blood flow (MBF), with a p-value of 0.044 for MBF improvement compared to postmeal administration.
Key findings
- Glucose area under the curve was significantly greater with postmeal insulin (p=0.015).
- Myocardial microvascular flow velocity significantly increased with premeal insulin (p=0.031).
- Premeal insulin administration led to greater myocardial MBF (p=0.044).
Why it matters
Understanding the impact of insulin timing on postprandial glucose levels and myocardial blood flow can inform treatment strategies for individuals with type 1 diabetes, potentially improving cardiovascular outcomes.