Effect of low-dose rivaroxaban plus aspirin on 18F-FDG PET/CT-detectable carotid plaque inflammation: a randomized trial.
Tae Oh Kim, Sangwon Han, Jeongryul Ryu et al.
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In 30 seconds
This randomized controlled trial evaluated the effect of low-dose rivaroxaban combined with aspirin on carotid plaque inflammation in 92 adults with asymptomatic carotid stenosis. The primary outcome, the percent change in the most diseased segment TBR at 12 months, showed no significant difference between the combination therapy (-7.25%) and aspirin alone (-7.36%), with an adjusted between-group difference of -1.50 percentage points (P = 0.529).
Key findings
- Mean percent change in MDS TBR was -7.25% with combination therapy and -7.36% with aspirin alone.
- The adjusted between-group difference in TBR change was -1.50 percentage points (P = 0.529).
- Minor bleeding occurred in 8.7% of patients on combination therapy and 2.2% on aspirin alone.
- No major bleeding or deaths were reported during the study.
Why it matters
Understanding the impact of combination therapy on arterial inflammation is crucial for managing patients with atherosclerosis. This study suggests that adding low-dose rivaroxaban to aspirin does not enhance the reduction of carotid plaque inflammation, which may influence treatment decisions.