Endobronchial Spindle Cell Tumor of Neurogenic Origin with Coexisting Bronchial Anthracofibrosis: A Rare Case Report.

Ann Afr MedJul 15, 2026 (epub)
Case ReportPulmonologyPathology (Anatomic & Clinical)Radiology (Diagnostic)Nuclear Medicine

K P Shaily, Navothna Somireddy, Shrividya Sethuratnam

✦ AI-curated · Sources linked

Case in brief

A 69-year-old nonsmoking woman with progressive breathlessness had a 45-year history of exposure to biomass smoke. CT showed right middle-lobe atelectasis with microcalcification and extensive mediastinal lymphadenopathy; FDG PET-CT demonstrated avidity in the right middle-lobe bronchus and multiple lymph nodes. Bronchoscopy found bronchial narrowing and endobronchial obstruction. Histopathology and immunohistochemistry identified a low-grade spindle cell tumor of neurogenic origin, described as neurofibroma/schwannoma, with coexisting bronchial anthracofibrosis. After comprehensive staging, she received multidisciplinary management; the abstract does not specify treatment or outcome beyond reporting a favorable prognosis.

What made this case unusual

The tumor’s endobronchial location and neurogenic origin occurred alongside bronchial anthracofibrosis, in a nonsmoking woman with prolonged biomass-smoke exposure.

Diagnostic / clinical pearl

In airway obstruction with imaging abnormalities, bronchoscopic sampling and histopathology with immunohistochemistry can establish the nature of an endobronchial spindle cell lesion, even when imaging shows FDG-avid lymph nodes.

Source

PubMed · PMID 42458959

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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