Eyelid Verrucous Sporotrichosis Caused by Sporothrix Brasiliensis Mimicking Cutaneous Leishmaniasis and Complicated by Drug-Drug Interaction.
Felipe Tavares Rodrigues, Amanda Ribeiro Dos Santos, Sandro Rogério de Almeida et al.
✦ AI-curated · Sources linked
Case in brief
A 28-year-old woman presented with verrucous sporotrichosis of the eyelid, resembling cutaneous leishmaniasis, despite no history of cat exposure or trauma. Initial diagnostic tests were inconclusive, and treatment with oral itraconazole was ineffective. Diagnosis was confirmed through fungal culture and PCR. The lesion resolved after switching to oral terbinafine for three months.
What made this case unusual
The case is notable for the misdiagnosis of cutaneous leishmaniasis and the role of drug-drug interaction, as concurrent use of pantoprazole likely impaired itraconazole absorption.
Diagnostic / clinical pearl
Clinicians should consider sporotrichosis in the differential diagnosis of chronic verrucous lesions in endemic areas, even when initial tests are inconclusive.
Why it matters
This case underscores the importance of evaluating potential drug-drug interactions that can affect antifungal treatment efficacy.