Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response-A Randomized, Placebo-Controlled Trial.
Clin Pharmacol TherJul 21, 2026 (epub)
Boukje C Eveleens Maarse, Aliede E In 't Veld, Hendrika W Grievink et al.
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In 30 seconds
This randomized, placebo-controlled trial examined the immune response to oral cholera vaccination (OCV) in 16 healthy volunteers, focusing on the effects of mycophenolate mofetil (MMF). Results indicated significant serum IgA and IgG responses post-vaccination, with MMF-treated individuals showing a cholera antibody response that suggested potential suppression, although not statistically significant.
Key findings
- Significant serum IgA and IgG responses were observed after OCV.
- MMF-treated volunteers exhibited a cholera antibody response, indicating potential suppression.
- No substantial IgA response was detected in saliva post-vaccination.
- PBMC analysis revealed Th2 skewing with increased cytokine production in the OCV group.
Why it matters
Understanding the impact of immunosuppressive therapies like MMF on vaccination responses is crucial for optimizing immunization strategies in vulnerable populations, such as organ transplant recipients.