Therapeutic plasma exchange in pediatric streptococcal toxic shock syndrome with severe digital ischemia.
Emine Pinar Kulluoglu, Gokcen Ozcifci
✦ AI-curated · Sources linked
Case in brief
A 2.5-year-old boy with group A β-hemolytic Streptococcus infection developed catecholamine-resistant septic shock, respiratory failure, and acute kidney injury, leading to worsening thrombocytopenia and severe microcirculatory dysfunction indicative of thrombocytopenia-associated multiple organ failure (TAMOF). Therapeutic plasma exchange was initiated as part of a multimodal treatment approach, resulting in stabilized peripheral perfusion and avoidance of amputation. The patient ultimately recovered without functional deficits.
Diagnostic / clinical pearl
Clinicians should be vigilant for complications of streptococcal toxic shock syndrome, such as TAMOF, and consider therapeutic plasma exchange as part of a comprehensive management strategy in severe cases.