Does Doxycycline Benefit Intensified Hygiene Measures in Patients with Filarial Lymphedema? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Am J Trop Med HygJul 23, 2026 (epub)
Asia Batool, Makhzan Ali Akbar, Fakhar E Mahin et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of doxycycline combined with intensified hygiene measures in patients with bancroftian filariasis. Analyzing 12 randomized controlled trials, the study found a significant reduction in Wolbachia per microfilaria (MD = -3.09; 95% CI: -3.94 to -2.25; P <0.00001). However, the evidence for microfilarial count reduction was unstable.
Key findings
- Doxycycline significantly reduced Wolbachia per microfilaria (MD = -3.09; 95% CI: -3.94 to -2.25; P <0.00001).
- Microfilarial count reduction was highly heterogeneous (I2 = 99%) and nonsignificant upon sensitivity analysis.
- Vomiting was significantly more common in the doxycycline group (RR = 6.25; 95% CI: 2.14-18.24; P = 0.0008).
Why it matters
Understanding the efficacy of doxycycline in managing filarial lymphedema is crucial for developing effective treatment protocols. The findings highlight the need for careful consideration of treatment options in endemic populations.