Meta-analysis of prostacyclin therapy for persistent pulmonary hypertension with congenital diaphragmatic hernia.
Shouliang Jiang, Xue Han, Yang He et al.
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In 30 seconds
This meta-analysis evaluated the efficacy and safety of prostacyclin therapy for persistent pulmonary hypertension in infants with congenital diaphragmatic hernia, analyzing data from nine studies involving 7009 infants. The results indicated a statistically significant decrease in oxygenation index (Mean Difference 9.34; p < 0.00001), but no significant impact on mortality or other clinical outcomes.
Key findings
- Prostacyclin therapy resulted in a significant decrease in the oxygenation index (Mean Difference 9.34; p < 0.00001).
- No statistically significant effect on mortality was observed (OR 0.83; p = 0.70).
- High heterogeneity was noted in outcomes such as ECMO and ventricular septal curvature.
- Most outcomes were rated as very low quality, indicating substantial evidence heterogeneity.
Why it matters
Understanding the effects of prostacyclin on oxygenation in this vulnerable population is crucial for clinicians managing congenital diaphragmatic hernia. The findings highlight the need for careful consideration of treatment efficacy and safety.
What to keep in mind
The quality of evidence was generally low, with substantial heterogeneity across outcomes.