Global molecular and serological evidence of dengue and chikungunya infection: a systematic review and meta-analysis of 158,608 tested participants.
Mohammed Alissa, Abdullah Alghamdi, Suad A Alghamdi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated dengue virus (DENV) and chikungunya virus (CHIKV) infections in 158,608 participants across various studies. The pooled CHIKV positivity was 14.0% (95% CI: 12.0-16.4), while DENV positivity was 13.8% (95% CI: 10.9-17.3). Notably, DENV-CHIKV co-infection was found in 52.9% of cases where both viruses were tested.
Key findings
- Pooled CHIKV positivity was 14.0% (95% CI: 12.0-16.4).
- Pooled DENV positivity was 13.8% (95% CI: 10.9-17.3).
- DENV-CHIKV dual positivity/co-infection was 52.9% (95% CI: 48.7-57.1).
- Significant between-study heterogeneity was observed in DENV analyses.
Why it matters
Understanding the prevalence of DENV and CHIKV is crucial for clinicians in co-endemic regions, as it informs diagnostic approaches and public health strategies to manage outbreaks effectively.
What to keep in mind
The study highlights substantial between-study heterogeneity and variability in diagnostic methods, which may affect the reliability of the pooled estimates.