Dual infection: disseminated histoplasmosis and peritoneal tuberculosis in a HIV-negative immunocompetent patient. A case report.
Luis Avellano-Khan, Neil Stone, Justin Edwards et al.
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Case in brief
A clinically immunocompetent man with type 2 diabetes mellitus presented with symptoms leading to the diagnosis of dual infection: culture-confirmed disseminated histoplasmosis and peritoneal tuberculosis. This case highlights the complexities of diagnosing and managing overlapping infections in a non-endemic country. The patient was treated with concurrent antifungal and antitubercular therapies, addressing both infections effectively.
What made this case unusual
The case is notable for the occurrence of disseminated histoplasmosis in an HIV-negative, immunocompetent individual, which is atypical given the usual demographic affected by this fungal infection.
Diagnostic / clinical pearl
Clinicians should be aware of the potential for dual infections like histoplasmosis and tuberculosis, especially in patients with overlapping symptoms and risk factors.
Why it matters
This case underscores the importance of considering rare infections in non-endemic regions, as misdiagnosis can lead to inappropriate treatment and increased morbidity.