Human pulmonary infection by Brucella suis vaccine strain S2 revealed by genome sequencing in China.
Kun Li, Xiaoyan Zhou, Lingling Tian et al.
✦ AI-curated · Sources linked
Case in brief
A 77-year-old woman presented with a three-year history of coughing and expectoration, ultimately diagnosed with brucellosis through next-generation sequencing. The isolate was identified as Brucella suis vaccine strain S2, showing 99.9996% nucleotide identity to the vaccine strain. Despite no known animal contact, a B. suis S2-like strain was found in a milk sample, suggesting a potential source of infection.
Diagnostic / clinical pearl
Clinicians should consider the possibility of human infection from Brucella vaccine strains, particularly in patients with unexplained respiratory symptoms.
Why it matters
This case highlights the need for further investigation into the virulence and transmission routes of Brucella vaccine strains to prevent future infections.