From multi-target to network synergy: A systematic review of how traditional Chinese medicine acts against myocardial ischemia-reperfusion injury via miRNA-mediated systemic communication.
Pharmacol ResJul 27, 2026 (epub)
Clinical ResearchCardiology
De-Sheng Xu, Jiang-Xuan He, Jia-Hui Yan et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review examines how traditional Chinese medicine (TCM) influences myocardial ischemia-reperfusion injury (MIRI) through microRNA (miRNA) networks. Analyzing 53 preclinical studies, the review highlights that TCM compounds can regulate cardiac miRNAs to reduce apoptosis, oxidative stress, and inflammation. The findings suggest a dual approach for therapeutic development targeting both local and systemic effects.
Key findings
- TCM compounds can coordinately regulate clusters of cardiac miRNAs to reduce apoptosis, oxidative stress, and inflammation.
- Evidence shows that TCM can alter extracellular vesicle miRNAs from various tissues to impact cardiac health.
- A proposed two-tiered therapeutic framework includes targeting miRNA hubs and guiding EV miRNA cargo.
Why it matters
Understanding the mechanisms by which TCM affects miRNA networks could lead to innovative therapeutic strategies for managing myocardial ischemia-reperfusion injury, an area with limited effective treatments.