Haemodynamic responses to head-up tilt versus lower-body negative pressure in type 1 diabetes.
Exp PhysiolJul 28, 2026 (epub)
Victorien Faivre-Rampant, Jules Warnier, Perrine Larmet et al.
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In 30 seconds
This randomized controlled trial examined the hemodynamic responses to head-up tilt (HUT) and lower-body negative pressure (LBNP) in 30 young adults, including 14 with type 1 diabetes. While both methods achieved similar reductions in thoracic blood volume, stroke volume decreased more during HUT compared to LBNP (P = 0.016), highlighting distinct cardiovascular adjustments between the two techniques.
Key findings
- Stroke volume decreased more during HUT than LBNP (P = 0.016).
- Cardiac output was maintained during HUT due to increased heart rate.
- Type 1 diabetics had higher heart rates but preserved stroke volume and cardiac output compared to controls.
- HUT induced splanchnic pooling, while LBNP promoted pelvic pooling.
Why it matters
Understanding the distinct cardiovascular responses to HUT and LBNP can aid clinicians in assessing autonomic function and managing patients with type 1 diabetes, particularly in relation to orthostatic regulation.