Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
Yu Shi, Yuqian Liu, Zihan Zhou et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of oral l-arginine on ambulatory blood pressure (ABP) across 5 randomized controlled trials involving 202 participants. The findings indicated that l-arginine supplementation significantly reduced 24-hour systolic blood pressure by 4.23 mmHg and diastolic blood pressure by 3.04 mmHg, both with p-values less than 0.01.
Key findings
- Oral l-arginine reduced 24h SBP by 4.23 mmHg (95% CI [-5.87, -2.58]; P < 0.01).
- 24h DBP decreased by 3.04 mmHg (95% CI [-4.48, -1.59]; P < 0.01).
- Daytime systolic blood pressure (dSBP) was reduced by 4.16 mmHg (95% CI [-5.90, -2.41]; P < 0.01).
- Nighttime systolic blood pressure (nSBP) decreased by 5.70 mmHg (95% CI [-7.81, -3.58]; P < 0.01).
Why it matters
The findings suggest that oral l-arginine may be an effective adjunctive therapy for managing blood pressure, potentially benefiting patients with hypertension. Understanding its effects on both daytime and nighttime blood pressure can inform treatment strategies.
What to keep in mind
The study was limited by the small number of included trials, indicating a need for further research to validate the findings.