A systematic review of paediatric-specific risk factors for nosocomial infections in paediatric intensive care units, 2005-2024.
J Hosp InfectJul 29, 2026 (epub)
Lingying Wang, Mei Feng, Yulan Luo et al.
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In 30 seconds
This systematic review analyzed 24 observational studies involving 74,960 children in pediatric intensive care units (PICUs) to identify risk factors for nosocomial infections (NIs). Key findings indicated that younger age, prolonged PICU stay, and invasive procedures were consistent risk factors. The review highlights the need for tailored infection control strategies to mitigate NIs in this vulnerable population.
Key findings
- Younger age and prolonged PICU stay were identified as consistent risk factors for all-site NIs.
- Prolonged mechanical ventilation and reintubation were independent risk factors for ventilator-associated pneumonia (VAP).
- Indwelling urinary catheters were a core risk factor for catheter-associated urinary tract infections (CA-UTIs).
- Administration of two or more antimicrobial agents was predictive of multi-drug-resistant infections (MDRIs).
Why it matters
Understanding pediatric-specific risk factors for nosocomial infections is crucial for developing effective infection prevention strategies in PICUs, ultimately reducing morbidity and healthcare costs associated with these infections.