Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis.
Michael I Brener, David J Cohen, Susheel K Kodali et al.
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In 30 seconds
This randomized trial compared patient-reported health status after transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) in low-surgical-risk patients with severe aortic stenosis. The analytic cohort comprised 943 PARTNER 3 participants who underwent their assigned procedure. Both groups had substantial improvements in health status sustained through 7 years. TAVR was associated with faster early recovery: the 1-month KCCQ overall summary score was 16.2 points higher than after SAVR (95% CI, 14.3-18.1). Differences were not significant in years 3-7, and about 60% in each group had an excellent outcome at 7 years.
Key findings
- At 1 month, KCCQ-OS scores were 16.2 points higher after TAVR than SAVR (95% CI: 14.3-18.1).
- The TAVR advantage was smaller at 2 years: mean difference +1.9 points (95% CI: 0.2-3.7); no significant differences were found in years 3-7.
- Both procedures improved KCCQ and Short Form-36 summary scores relative to baseline through 7 years.
- At 7 years, approximately 60% of patients in each group were alive with KCCQ-OS ≥75 and no decline ≥10 points from baseline.
Why it matters
Health status is an important patient-reported outcome alongside procedural and clinical measures. These findings indicate that both approaches can be followed by sustained improvement in low-risk patients, while TAVR offers a substantial early recovery advantage that diminishes over time. The long-term comparison helps frame discussions of recovery expectations without suggesting a persistent health-status advantage for either procedure.
What to keep in mind
The analytic cohort included only trial participants with baseline KCCQ assessments who underwent their assigned procedure, rather than all randomized patients.