Cryobiopsy versus conventional bronchoscopic sampling for peripheral pulmonary lesions (Cryo-RCT): an open-label, parallel-group, randomised trial.
Lancet Respir MedJul 29, 2026 (epub)
Yuji Matsumoto, Toshiyuki Nakai, Dongil Park et al.
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In 30 seconds
This open-label, parallel-group, randomised trial evaluated the diagnostic yield of cryobiopsy versus conventional bronchoscopic sampling in 627 patients with peripheral pulmonary lesions. Cryobiopsy demonstrated a higher histology-based diagnostic yield of 83% compared to 75% for conventional sampling (estimated difference 8.9%, p=0.0023).
Key findings
- In the adjacent-to or eccentric cohort, diagnostic yield was 77% for cryobiopsy versus 65% for conventional sampling (estimated difference 12.4%, p=0.0060).
- Moderate bleeding occurred in 38% of patients in the cryobiopsy group compared to 19% in the conventional group.
- Pneumothorax occurred in 2% of patients in the cryobiopsy group versus <1% in the conventional group.
Why it matters
The study highlights the potential of cryobiopsy to improve diagnostic yield in patients with peripheral pulmonary lesions, which may enhance clinical decision-making and patient management.