Assessment of Trypanosoma cruzi seroprevalence and diagnostic evolution in Mexican blood banks: A systematic review.
Acta TropJul 29, 2026 (epub)
Carmen Guzmán-Bracho, Aracely López-Monteon, Anahí Sosa-Arroniz et al.
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In 30 seconds
This systematic review evaluated the seroprevalence of Trypanosoma cruzi in Mexican blood banks from 2005 to 2025, analyzing 19 studies. The pooled mean seroprevalence was 1.0%, significantly higher than the national baseline of 0.23% for 2024. The review highlights the ongoing risk of Chagas disease transmission through blood transfusion in Mexico.
Key findings
- Pooled mean seroprevalence of T. cruzi was 1.0%, compared to the national baseline of 0.23%.
- Enzyme-linked immunosorbent assay (ELISA) was used in 94.4% of the studies reviewed.
- Data were reported from only 12 of the 32 Mexican states, indicating limited geographic coverage.
- The study populations were predominantly male, comprising 82.8% of the total.
Why it matters
Understanding the seroprevalence of T. cruzi is crucial for assessing blood safety and implementing effective screening strategies. This review emphasizes the need for improved diagnostic practices and targeted surveillance to mitigate the risk of Chagas disease transmission through transfusions.