Fulminant heart failure in a patient with MYPN-associated cardiomyopathy: A case report.
Manroop Minhas, Abdullah Amir, Fuad Hassuneh et al.
✦ AI-curated · Sources linked
Case in brief
A 48-year-old African American woman with MYPN-associated nonischemic cardiomyopathy presented with acute ischemic stroke after missing anticoagulation therapy. Her condition included an ejection fraction of less than 15%, atrial fibrillation, and a left ventricular thrombus. Despite undergoing mechanical thrombectomy and receiving maximal guideline-directed therapy, she experienced recurrent ventricular tachycardia, refractory heart failure, acute kidney injury, sepsis, and multi-organ dysfunction.
Diagnostic / clinical pearl
MYPN mutations can lead to rapid progression of cardiomyopathy and severe complications, emphasizing the need for early genetic testing and timely referral for advanced therapies.
Why it matters
This case illustrates the systemic complications associated with MYPN-associated cardiomyopathy, highlighting the importance of proactive management in similar patients.