Genomic analysis of a clinical Enterobacter hormaechei isolate from a postoperative left atrial myxoma patient.
Jinzhen Zhao, Miaoxian Fang, Liming Lei et al.
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From the abstract
Enterobacter hormaechei is an opportunistic pathogen increasingly implicated in healthcare-associated infections, including bloodstream infections. However, the genomic and pathogenic features of clinical isolates from specific surgical settings remain incompletely characterized.
Reported results
The FLZ genome comprised 4,609,213 bp with a GC content of 55.3%, encoding 4377 predicted genes. Phylogenomic analysis confirmed its classification as E.hormaechei subsp. xiangfangensis (99.09% ANI with the type strain). The isolate carried resistance-associated genes and efflux pump components.
Authors' conclusions
This study provides genomic and in vivo evidence characterizing the pathogenic potential of an E. hormaechei clinical isolate from a rare postoperative setting. The findings highlight the need for enhanced surveillance and further functional studies to elucidate the virulence mechanisms of this emerging pathogen.