Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study.
Crit Care MedAug 3, 2026 (epub)
Nicolas Fage, Madjid Bouizegarene, Valerie Seegers et al.
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In 30 seconds
This randomized controlled trial examined the relationship between renal resistive index (RRI) responsiveness to mean arterial pressure (MAP) testing and renal outcomes in patients with early septic shock. Among 80 patients, 29% were RRI responders. The study found that higher MAP targets did not improve renal outcomes for RRI responders, while nonresponders showed increased urine output at higher MAP levels.
Key findings
- 29% of patients were identified as RRI responders during the MAP test.
- Higher MAP targets did not improve renal outcomes for RRI responders.
- RRI nonresponders had higher urine output with a high MAP target.
- No significant differences in other renal parameters were observed.
Why it matters
Understanding the relationship between MAP targets and renal function in septic shock can guide clinicians in optimizing treatment strategies. This study suggests that RRI responsiveness may not reliably predict renal benefit from higher MAP targets.