Transvalvular Flow Rate is Associated With Mortality Rate and Lifetime Loss in Aortic Valve Stenosis: A Meta-Analysis of Reconstructed Time-to-Event Data.
Am J CardiolAug 3, 2026 (epub)
Clinical ResearchCardiology
Michel Pompeu Sá, Christian Ken Fukunaga, Iago T C Grillo et al.
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In 30 seconds
This meta-analysis examined the association between transvalvular flow rate (TFR) and mortality in patients with aortic stenosis (AS), analyzing data from 9 studies with 6,494 patients. It found that low TFR was linked to a higher all-cause mortality rate, with a hazard ratio of 1.59 (95% CI 1.45 to 1.74, p < 0.001) and a lifetime loss of 2.3 years compared to normal TFR.
Key findings
- At 8 years, survival was 34.1% in the low-TFR group versus 63% in the normal-TFR group.
- Low TFR was associated with a hazard ratio of 1.59 for all-cause mortality.
- The lifetime loss in the low-TFR group was 2.3 years compared to the normal-TFR group.
Why it matters
Understanding the prognostic implications of TFR in aortic stenosis can aid clinicians in risk stratification and management decisions, potentially improving patient outcomes through targeted interventions.