Association of the T-786C polymorphism of the nitric oxide synthase 3 gene with acute coronary syndrome or premature coronary artery disease: A systematic review and meta-analysis.
CytokineAug 6, 2026 (epub)
Clinical ResearchCardiology
Himanshu Rai, J J Coughlan, Daniel O'Callaghan et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the association of the T-786C polymorphism in the NOS3 gene with acute coronary syndrome (ACS) and premature coronary artery disease (PCAD) across 23 studies involving 17,324 subjects. The analysis revealed a significant association, with an odds ratio of 1.26 (95% CI, 1.09-1.45, p = 0.001) for ACS and PCAD.
Key findings
- The T-786C polymorphism was associated with ACS and PCAD with an odds ratio of 1.26.
- Pooled analysis showed a significant association in both dominant and allelic genetic models.
- Sensitivity analysis confirmed the robustness of the findings.
- The study included data from 23 studies involving 17,324 subjects.
Why it matters
Understanding genetic risk factors like the T-786C polymorphism can help identify individuals at higher risk for acute coronary syndrome and premature coronary artery disease, potentially guiding preventive strategies.