From gut to heart: the emerging role of dietary fermentable fiber in heart failure with preserved ejection fraction.
Faisal Darbar, Medha Priyadarshini, Yueyang Wang et al.
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In 30 seconds
This systematic review examines the role of dietary fermentable fiber (FF) and short-chain fatty acids (SCFAs) in heart failure with preserved ejection fraction (HFpEF). It synthesizes evidence from preclinical and clinical studies, highlighting that FF interventions can enhance SCFA levels and improve metabolic outcomes. Notably, FF interventions were associated with improved insulin sensitivity and reduced low-density lipoprotein cholesterol.
Key findings
- A systematic review of 27 human randomized controlled trials showed FF interventions improve insulin sensitivity and reduce low-density lipoprotein cholesterol.
- Preclinical studies indicate that FF supplementation improves cardiometabolic function and attenuates cardiac remodeling.
- Direct SCFA supplementation provides modest metabolic benefits, including reduced adiposity and liver fat.
Why it matters
Understanding the impact of dietary fermentable fiber on HFpEF could lead to novel therapeutic strategies, especially given the limited treatment options currently available for this condition. Enhancing gut health may improve overall cardiovascular outcomes.