Efficacy and safety of nasal saline irrigation for allergic rhinitis in children and adolescents: A systematic review and meta-analysis with GRADE assessment.
Int J Pediatr OtorhinolaryngolAug 10, 2026 (epub)
Safya E Esmaeel, Reem Ibrahim S Alanazi, Osama Omar A Albladi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of nasal saline irrigation (NSI) for allergic rhinitis in children and adolescents. Analyzing seven studies with 462 participants, the results indicated a significant reduction in nasal symptom scores (SMD -1.29; 95% CI -1.98 to -0.60) and decreased rescue antihistamine use (SMD -1.38; 95% CI -2.50 to -0.26), although evidence certainty was low to very low.
Key findings
- NSI led to a significant reduction in nasal symptom scores (SMD -1.29; 95% CI -1.98 to -0.60).
- There was a significant decrease in rescue antihistamine use (SMD -1.38; 95% CI -2.50 to -0.26).
- A trend toward improved disease control was observed (SMD 0.53), but not statistically significant.
- Adverse events were minor and infrequent, with no serious safety concerns reported.
Why it matters
The findings suggest that nasal saline irrigation can provide meaningful symptom relief and reduce reliance on medications in pediatric patients with allergic rhinitis, potentially enhancing treatment strategies.