Interventions with a significant mortality difference in acute respiratory distress syndrome: A systematic review and comparison with Guidelines.
J Crit CareAug 11, 2026 (epub)
Chiara Sartini, Roberta Stati, Alessandro Belletti et al.
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In 30 seconds
This systematic review analyzed 33 randomized controlled trials (RCTs) to compare interventions with significant mortality differences in acute respiratory distress syndrome (ARDS) against European and American guidelines. The review found that 76% of RCTs reported mortality reduction, while 24% indicated increased mortality. Notably, eight effective interventions were not included in the guidelines.
Key findings
- 76% of RCTs (25/33) showed a mortality reduction in ARDS patients.
- 24% of RCTs (8/33) were associated with increased mortality.
- Eight interventions demonstrated reduced mortality but were not mentioned in the guidelines.
- 73% of the studies were multicenter, and 58% employed blinding.
Why it matters
Understanding the discrepancies between RCT findings and clinical guidelines is crucial for improving ARDS management. Identifying effective interventions not currently recommended could enhance patient outcomes and inform future research directions.