From human papillomavirus (HPV) infection to HPV-associated cancers in systemic lupus erythematosus: A systematic review and Meta-analysis.
Prev MedAug 11, 2026 (epub)
Hongli Wang, Huike Ma, Ruonan Li et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the risk of HPV infection and associated cancers in patients with systemic lupus erythematosus (SLE). The study found that SLE patients had significantly increased odds of HPV infection (OR = 4.12) and elevated risks for HPV-associated cancers (SIR = 1.90), with cervical cancer risk more than doubled (SIR = 2.25).
Key findings
- SLE patients had an odds ratio of 4.12 for HPV infection (95% CI 2.03, 8.32).
- The standardized incidence ratio for HPV-associated cancers in SLE was 1.90 (95% CI 1.51, 2.38).
- Cervical cancer risk in SLE patients was significantly elevated with an SIR of 2.25 (95% CI 1.75, 2.89).
- Vulvar/vaginal cancer risk was particularly high, with an SIR of 5.60 (95% CI 3.71, 8.43).
Why it matters
Understanding the heightened risk of HPV infection and associated cancers in SLE patients is crucial for clinicians. This knowledge can inform screening practices and risk management strategies, particularly for extra-cervical cancers that may be overlooked in current paradigms.