Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial.
Crit Care MedAug 12, 2026 (epub)
Ryo Yamamoto, Takahiro Yamanaka, Daiki Kaito et al.
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In 30 seconds
This post hoc analysis of a multicenter randomized controlled trial examined frailty progression in older adults (≥65 years) recovering from septic shock. Among 339 survivors, 30.4% had no-to-mild frailty, while 36.0% had severe frailty at 90 days. Key predictors of severe frailty included higher presepsis Clinical Frailty Scale scores (aOR, 2.03) and corticosteroid use (aOR, 1.72).
Key findings
- 30.4% of survivors had no-to-mild frailty, 33.6% had moderate frailty, and 36.0% had severe frailty at 90 days.
- Higher presepsis Clinical Frailty Scale scores were associated with increased frailty (aOR, 2.03 per 1-point increase).
- Corticosteroid use was linked to frailty deterioration (aOR, 1.72).
- Higher SOFA scores were associated with frailty in patients with tissue hypoperfusion.
Why it matters
Understanding the factors contributing to frailty in older patients recovering from septic shock is crucial for improving post-ICU care and quality of life. Identifying at-risk patients can guide interventions to mitigate frailty progression.