Glycaemic variation and atrial fibrillation burden and progression in individuals without diabetes undergoing continuous rhythm monitoring.
August Krebs Hessellund, Ketil Jørgen Haugan, Lucas Yixi Xing et al.
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In 30 seconds
This randomized controlled trial analyzed 884 participants without diabetes from the LOOP Study to assess the relationship between glycaemic variation and atrial fibrillation (AF) burden. Results indicated that higher HbA1c levels correlated with increased AF burden, with AF burden percentages of 0.52%, 0.78%, and 4.42% for normal, prediabetic, and diabetic HbA1c levels, respectively. A 1 mmol/mol increase in HbA1c was linked to a 5% relative increase in AF burden.
Key findings
- AF burden was 0.52% for normal, 0.78% for prediabetic, and 4.42% for diabetic HbA1c levels.
- A 1 mmol/mol increase in HbA1c was associated with a 5% relative increase in AF burden.
- Participants with prediabetes or diabetes had longer AF durations compared to those with normal HbA1c.
Why it matters
Understanding the link between glycaemic levels and AF burden can help clinicians identify at-risk patients and potentially guide monitoring strategies for those with glycaemic dysregulation.