Association Between Follow-Up Mean Blood Pressure and Blood Pressure Control: A Meta-Regression Analysis of 101 Randomized Trials.
HypertensionAug 17, 2026 (epub)
Abdul Salam, Rupasvi Dhurjati, Rashmi Pant et al.
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In 30 seconds
This meta-regression analysis examined the relationship between mean blood pressure (BP) and BP control in 101 randomized trials involving over 85,000 participants. The study found that a mean systolic BP (SBP) of 125 mm Hg was associated with approximately 80% achieving BP control, indicating that lower SBP correlates with better control rates.
Key findings
- Mean SBP of 120, 125, 130, and 135 mm Hg corresponded to BP control in 85%, 75%, 65%, and 55% of participants in individual RCTs.
- Each 1 mm Hg reduction in mean SBP was associated with approximately a 2% increase in BP control.
- An SBP below 125 mm Hg was linked to achieving BP control in approximately 80% of patients.
Why it matters
Understanding the relationship between mean BP and control rates is crucial for clinicians to optimize hypertension management and improve patient outcomes. These findings can help inform treatment strategies and guideline recommendations.