Exhaled breath volatile organic compounds in cystic fibrosis: a systematic review.
Malika Mustafina, Stanislav Krasovskiy, Alexander Chernyak et al.
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In 30 seconds
This systematic review examined volatile organic compounds (VOCs) in the exhaled breath of cystic fibrosis (CF) patients to identify potential clinical biomarkers. Out of 431 records, 27 studies were included, revealing 121 VOCs associated with CF. Notably, compounds like hydrogen cyanide and dimethyl sulfide were frequently identified, indicating their relevance to bacterial colonization and inflammation.
Key findings
- A total of 121 VOCs were reported in association with cystic fibrosis.
- Compounds such as hydrogen cyanide and dimethyl sulfide may serve as potential biomarkers.
- Substantial heterogeneity was observed in study design and methodologies across included studies.
- Standardized protocols and multicenter studies are essential for clinical implementation.
Why it matters
Identifying reliable biomarkers for cystic fibrosis through non-invasive breath analysis could enhance disease monitoring and guide therapeutic decisions, ultimately improving patient outcomes.
What to keep in mind
Substantial heterogeneity in study design, patient populations, and analytical methodologies was noted.