Safe and Fast Radial Artery Hemostasis Using Synergistic Strategies: SAFE and FAST Trial.
Am J CardiolAug 19, 2026 (epub)
Clinical ResearchCardiology
Khyati Khattar, Anurag Barot, Aman T Patel et al.
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In 30 seconds
The SAFE and FAST trial evaluated hemostasis strategies in patients undergoing transradial access for cardiac catheterization at two centers. In a randomized controlled trial involving 451 patients, a dual-balloon device with lower heparin dosage resulted in a significant reduction in the primary endpoint of radial artery occlusion, rebound bleeding, or hematoma formation (4% vs 10.3%, p = 0.01).
Key findings
- Group 2 had a primary endpoint occurrence of 4% compared to 10.3% in Group 1 (p = 0.01).
- Patent hemostasis was achieved in 97% of Group 2 patients versus 81% in Group 1 (p = 0.001).
- Group 2 required significantly fewer nursing visits, averaging 3.1 compared to 5.3 in Group 1 (p = 0.001).
- The mean duration of compression was reduced by 62 minutes in Group 2 (p = 0.001).
Why it matters
This study highlights the potential for improved patient outcomes and efficiency in cardiac catheterization procedures through optimized hemostasis strategies, which may reduce complications and resource utilization.