Changes in sexual behavior among women in studies evaluating the dapivirine vaginal ring for HIV prevention.
Sex HealthSep 6, 2026
Kudzai Hlahla, Moni Neradilek, Morgan Garcia et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial analyzed sexual behavior changes among women participating in the dapivirine vaginal ring studies, MTN 020/ASPIRE and MTN-025/HOPE. The study involved HIV-negative women from Malawi, South Africa, Uganda, and Zimbabwe. Results indicated that sex with nonprimary partners increased in HOPE (13.9-18.7%) compared to ASPIRE (10.7-12.6%), with an adjusted odds ratio of 1.47.
Key findings
- Sex with nonprimary partners increased from 10.7-12.6% in ASPIRE to 13.9-18.7% in HOPE.
- Adjusted odds ratio for increased nonprimary partner sex was 1.47, 95% CI 1.24-1.75, P < 0.001.
- Condom use at last vaginal sex act remained similar: 36.5-42.7% in ASPIRE vs 43.6-46.7% in HOPE.
Why it matters
Understanding changes in sexual behavior during the use of HIV prevention methods like the dapivirine vaginal ring is crucial for developing effective reproductive health programs and addressing potential risk compensation.