Use of Expanded Access Fosmanogepix in Two Pediatric Patients With Rhino-Orbital-Cerebral Mucormycosis.

PharmacotherapySep 1, 2026
Case ReportInfectious DiseasesPediatricsOpen access

Misty M Oldham, Gwendolyn Buckendorf, Islam Elmitwalli et al.

✦ AI-curated · Sources linked

Case in brief

Two pediatric patients with diabetic ketoacidosis presented with extensive rhino-orbital-cerebral mucormycosis. Initial treatment with standard antifungal therapies failed to eradicate the infection. The addition of expanded access fosmanogepix to their treatment regimens led to significant improvement, allowing for the discontinuation of less tolerated antifungals. Both patients completed several months of fosmanogepix and survived their infections.

Diagnostic / clinical pearl

Fosmanogepix may be a viable option in the treatment of severe mucormycosis, especially when standard therapies are ineffective or poorly tolerated.

Source

PubMed · PMID 42618087Free full text on PubMed Central

Published in Pharmacotherapy. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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