MIC-based tuberculosis drug susceptibility testing using Sensititre MYCOTB: a diagnostic accuracy meta-analysis.
J Clin MicrobiolAug 20, 2026 (epub)
Clinical ResearchInfectious Diseases
Daniel Raj D, Mukesh Kumar G, Jitendra Singh et al.
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In 30 seconds
This meta-analysis evaluated the diagnostic performance of Sensititre MYCOTB for drug susceptibility testing in multidrug-resistant (MDR) and pre-extensively drug-resistant tuberculosis (pre-XDR TB). Analyzing 14 studies with 1,728 isolates, it found high sensitivity for rifampicin (0.976) and isoniazid (0.977), and high specificity for both drugs (0.958 and 0.957, respectively).
Key findings
- Rifampicin and isoniazid showed high sensitivity of 0.976 and 0.977, respectively.
- Specificity for rifampicin and isoniazid was 0.958 and 0.957, respectively.
- Amikacin, kanamycin, and ofloxacin demonstrated high specificity (>0.98).
- Moderate diagnostic accuracy was noted for ethambutol, streptomycin, ethionamide, and rifabutin.
Why it matters
Accurate drug susceptibility testing is essential for effective treatment of MDR and pre-XDR TB. The findings support the use of Sensititre MYCOTB in clinical settings to guide therapy decisions.