Quadriceps muscle behavior assessed by ultrasound in septic patients: A systematic review.
Vinicius P Cordeiro, Francisco Andrade, Stephanny Lima et al.
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In 30 seconds
This systematic review examined the use of ultrasound to assess quadriceps muscle atrophy in adults with sepsis or septic shock in ICUs. Analyzing six prospective cohorts with 234 patients, the review found that muscle thickness decreased by 10% to 30% during hospitalization. Greater muscle loss correlated with longer ICU stays and reduced strength post-discharge.
Key findings
- Quadriceps thickness decreased by 10% to 30% during ICU hospitalization.
- Greater muscle loss was linked to longer ICU stays and prolonged mechanical ventilation.
- All studies reported reductions in muscle mass or thickness post-admission.
- Ultrasound was identified as a feasible and repeatable tool for monitoring muscle in sepsis.
Why it matters
Understanding the extent of quadriceps atrophy in septic patients can help clinicians identify those at higher risk for poor outcomes, potentially guiding interventions to improve recovery and functional status.
What to keep in mind
Heterogeneity in measurement timing and metrics, along with small sample sizes, limited the ability to perform a meta-analysis.