Adjunctive Varicella-Zoster Virus-Specific Immunoglobulin for Complicated Varicella-Zoster Virus Infection in Kidney Transplant Recipients: Case Series.
Marina Kljajić, Lea Katalinić, Živka Dika et al.
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Case in brief
Three kidney transplant recipients presented with severe varicella-zoster virus (VZV) infections, including disseminated primary infection and herpes zoster with ocular involvement. They were treated with adjunctive VZV-specific intravenous immunoglobulin (VZV-IVIG) alongside standard antiviral therapy. All patients showed clinical stabilization and regression of symptoms, with one requiring multiple VZV-IVIG courses to manage persistent viremia and prevent further organ damage.
Diagnostic / clinical pearl
Adjunctive VZV-IVIG may be beneficial for kidney transplant recipients with severe or refractory VZV infections, especially those with persistent viremia or ocular complications.
Why it matters
This case series highlights the potential role of VZV-IVIG in managing complicated VZV infections in immunocompromised patients, suggesting a need for further research on its efficacy and optimal use.