Efficacy and Safety of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nurs Crit CareSep 1, 2026
Zhiqun Liu, Guiling Liao, Hui Wen et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of mechanical insufflation-exsufflation (MI-E) in invasively ventilated critically ill adults. Analyzing five randomized controlled trials with 310 patients, the study found that MI-E significantly increased sputum clearance (SMD = 0.63, p < 0.00011) without affecting oxygenation.
Key findings
- MI-E significantly increased sputum clearance with a standardized mean difference of 0.63.
- No serious adverse events were reported in the included studies.
- MI-E did not significantly affect oxygenation (MD = 0.28, p = 0.50).
- Data on respiratory mechanics and ICU stay could not be pooled.
Why it matters
The findings suggest that MI-E can enhance sputum clearance in critically ill patients on invasive ventilation, which may improve respiratory management. Understanding its safety profile is crucial for clinicians considering this intervention.