Acute dietary nitrate supplementation attenuates caffeine-induced increase in arterial stiffness in healthy adults: a randomized cross-over trial.
Abbie G McLellan, Nur S B Ahmad, Jarred P Acton et al.
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In 30 seconds
This randomized controlled trial investigated the effects of acute dietary nitrate supplementation on caffeine-induced arterial stiffness in 24 healthy adults. The study found that nitrate supplementation significantly attenuated the increase in arterial stiffness caused by caffeine, with augmentation pressure increasing by 3 mmHg after caffeine compared to only 1 mmHg with nitrate supplementation. Plasma nitrite levels were also higher with nitrate supplementation.
Key findings
- Caffeine increased arterial stiffness measures by 3 mmHg compared to 1 mmHg with nitrate supplementation.
- No significant differences in brachial or central blood pressure were observed between groups.
- Plasma nitrite levels were significantly higher in nitrate groups compared to placebo and caffeine groups.
Why it matters
Understanding the interaction between dietary nitrate and caffeine is crucial for managing cardiovascular health, particularly in individuals consuming caffeine regularly. This study suggests that nitrate supplementation may mitigate some adverse cardiovascular effects of caffeine.