Left Ventricular Global Longitudinal Strain as a Marker of Subclinical Myocardial Dysfunction in Youths With Type 1 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis.
Athina Stamati, Georgia Sotiriou, Elpida Emmanoulidou-Fotoulaki et al.
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In 30 seconds
This systematic review and meta-analysis evaluated Left Ventricular Global Longitudinal Strain (LV GLS) in youths with type 1 diabetes mellitus (T1DM) compared to healthy controls. The analysis included 18 studies with 1086 youths with T1DM and 935 controls, revealing a significant impairment in 2D LV GLS of -2.87% (95% CI -4.03 to -1.71), indicating early subclinical myocardial dysfunction.
Key findings
- Youths with T1DM exhibited a mean difference in 2D LV GLS of -2.87% compared to controls.
- The analysis included 18 studies with a total of 1086 youths with T1DM and 935 healthy controls.
- Substantial heterogeneity was observed in the results, with an I² of 96.2%.
- No significant differences were found in exploratory 3D GLS analysis.
Why it matters
The findings suggest that youths with T1DM may experience early signs of myocardial dysfunction, which could have implications for long-term cardiovascular health. Recognizing these changes early may help in risk stratification and management.
What to keep in mind
The study noted substantial heterogeneity and low certainty of evidence, indicating a need for further research.