Clinical frailty scale for risk stratification in elderly patients with heart failure: a meta-analysis.
Curr Probl CardiolAug 25, 2026 (epub)
Sneha Annie Sebastian, Amin Yehya
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In 30 seconds
This meta-analysis evaluated the prognostic value of the Clinical Frailty Scale (CFS) in 2,682 elderly patients with heart failure (mean age 81.2 years). Higher CFS scores were significantly associated with increased all-cause mortality (HR 2.39), HF hospitalization (HR 1.52), and a composite outcome of both (HR 1.75), indicating the CFS's utility in risk stratification.
Key findings
- Higher CFS scores correlated with a 2.39-fold increase in all-cause mortality.
- CFS scores were linked to a 1.52-fold increase in heart failure hospitalization.
- The composite outcome of all-cause mortality and HF hospitalization had an HR of 1.75.
- Sensitivity analysis showed robust associations with all-cause mortality, reducing heterogeneity to 0%.
Why it matters
Understanding frailty through the CFS can enhance risk stratification in elderly heart failure patients, allowing for more personalized management strategies and potentially improving patient outcomes.