Effects of acute and short-term grape seed extract supplementation on blood pressure responses to exercise in individuals at cardiometabolic risk: A randomised, double-blind, placebo-controlled exploratory crossover trial.
Alfonso Moreno-Cabañas, Lucia Gonzalez-Garcia, Diego Mora-Gonzalez et al.
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In 30 seconds
This randomized, double-blind, placebo-controlled crossover trial examined the effects of grape seed extract (GSE) supplementation on blood pressure responses to exercise in ten sedentary adults with elevated blood pressure and obesity. The study found that GSE intake led to lower ambulatory systolic blood pressure by -3.1 mmHg (acute) and -3.5 mmHg (short-term) and improved endothelial function, although it did not significantly affect post-exercise hypotension.
Key findings
- GSE supplementation resulted in a reduction of ambulatory systolic BP by -3.1 mmHg (acute) and -3.5 mmHg (short-term).
- Mean arterial pressure during exercise decreased by -4.4 mmHg (acute) and -5.1 mmHg (short-term) with GSE.
- Acute GSE intake enhanced flow-mediated dilation by 2.42%.
- Resting mean arterial pressure decreased by -6.2 mmHg after 7 days of GSE supplementation.
Why it matters
Understanding the potential of non-pharmacological interventions like grape seed extract could provide additional strategies for managing blood pressure in individuals at cardiometabolic risk, complementing traditional exercise regimens.