Duration-Dependent Cardiac Effects of Anabolic-Androgenic Steroid Use in Strength-Trained Athletes: A Systematic Review and Meta-Analysis.
Matheus de Medeiros Fernandes, Pedro Gomes Batista, Camila Viviane Ribera Chagas et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the cardiac effects of anabolic-androgenic steroid (AAS) use in strength-trained athletes, analyzing data from 40 studies involving 1906 athletes. AAS users exhibited a significant reduction in left ventricular ejection fraction (LVEF) by 2.84% and increased left ventricular mass index (LVMI) by 18.21 g/m². The study highlights the duration-dependent nature of these cardiac effects.
Key findings
- AAS users had a reduced left ventricular ejection fraction (LVEF) of -2.84%.
- Left ventricular mass index (LVMI) increased by 18.21 g/m² in AAS users.
- The largest LVEF reduction was observed in users with exposure beyond six years, at -7.39%.
- Septal thickening was detectable in AAS users before six months of use.
Why it matters
Understanding the cardiac effects of AAS use is crucial for clinicians, as these substances are increasingly used in strength training. The findings underscore the potential for significant cardiac abnormalities, particularly with prolonged use, which may inform monitoring and management strategies.