Longitudinal Serum Uric Acid Variation and Risk of Major Adverse Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis.
Saima Nisar, Asif Shah, Abida Perveen
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In 30 seconds
This systematic review and meta-analysis examined the relationship between longitudinal serum uric acid (SUA) variation and major adverse cardiovascular events (MACE) and mortality in adults. Analyzing six cohort studies with 160,640 participants, the study found that greater SUA variability was associated with increased risks of all-cause mortality (HR 1.18), incident cardiovascular disease (HR 1.21), and cardiovascular mortality (HR 1.25).
Key findings
- Greater longitudinal SUA variation linked to all-cause mortality (HR 1.18, 95% CI 1.10-1.27).
- Increased risk of incident cardiovascular disease/MACE (HR 1.21, 95% CI 1.11-1.32).
- Higher cardiovascular mortality risk associated with SUA variation (HR 1.25, 95% CI 1.10-1.42).
- One study indicated increased heart failure-related outcomes (HR 1.31, 95% CI 1.12-1.54).
Why it matters
Understanding the implications of SUA variability can enhance cardiovascular risk assessment, allowing clinicians to identify patients at higher risk for adverse outcomes and mortality, potentially leading to improved management strategies.