Acute kidney injury after aminoglycoside exposure in two cystic fibrosis patients receiving triple CFTR modulator therapy.
Deslais Martin, Novel-Catin Etienne, Nove-Josserand Raphaële et al.
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Case in brief
Two patients with cystic fibrosis developed acute kidney injury after their first aminoglycoside exposure while receiving triple CFTR modulator therapy. The report describes the temporal association but does not provide further clinical findings, diagnostic work-up, management, or outcomes. The authors proposed that modulator therapy may have restored proximal tubular reabsorption of aminoglycosides, potentially increasing renal exposure and toxicity; this mechanism was presented as a hypothesis.
What made this case unusual
Acute kidney injury followed first-time aminoglycoside exposure in patients already receiving triple CFTR modulator therapy, prompting a hypothesis that restored proximal tubular reabsorption could increase aminoglycoside toxicity.
Diagnostic / clinical pearl
In a patient with cystic fibrosis receiving triple CFTR modulator therapy, consider the possibility of acute kidney injury after aminoglycoside exposure; the proposed mechanism remains hypothetical.