Supplementations of docosahexaenoic acid and blueberry suppress a high-fat breakfast-induced postprandial inflammation but only docosahexaenoic acid improves endothelial function in healthy adults: a randomized, double-blind, placebo-controlled crossover intervention study.
Shurong Huang, Catherine Kirschke, Rémy Bosviel et al.
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In 30 seconds
This randomized, double-blind, placebo-controlled crossover study evaluated the effects of blueberry powder (BBP) and docosahexaenoic acid (DHA) on postprandial inflammation and endothelial function in 62 healthy adults. DHA significantly suppressed high-fat meal-induced inflammation, reducing IL-1β expression by 21.6% and improving endothelial function with a 13.3% increase in reactive hyperemia index at 6 hours compared to placebo.
Key findings
- DHA reduced IL-1β expression by 21.6% (P < .01) at 6 hours post-meal.
- DHA improved the total cholesterol/HDL cholesterol ratio by 3.5% (P < .0001) at 6 hours.
- BBP suppressed LPL-treated blood IL-1β production by 23.1% (P < .05) at 6 hours.
- DHA increased reactive hyperemia index scores by 13.3% (P < .05) compared to placebo at 6 hours.
Why it matters
Understanding the effects of dietary supplements like DHA and blueberries on postprandial inflammation and endothelial function can inform dietary recommendations aimed at reducing cardiovascular risk and improving metabolic health.