A Meta-Analysis of Human Immunodeficiency Virus Drug Resistance in Pakistan.
Shafee Ur Rehman
✦ AI-curated · Sources linked
In 30 seconds
This meta-analysis examined HIV drug resistance (HIVDR) in Pakistan, analyzing data from 51 studies involving over 1,500 participants from 2015 to 2025. The study found that 35% of ART-experienced patients exhibited HIVDR. Resistance mutations were prevalent in the reverse transcriptase and protease regions, with notable increases in NNRTI resistance over the past decade.
Key findings
- 35% of ART-experienced patients developed HIV drug resistance (95% CI: 30-40%).
- The most common NNRTI resistance mutations included M184V, K103N, L90M, and M46I.
- NNRTI resistance has increased over the past decade.
- The analysis included 51 studies with more than 1,500 participants.
Why it matters
Understanding the prevalence and patterns of HIV drug resistance is crucial for optimizing antiretroviral therapy and controlling the HIV epidemic. This knowledge can inform treatment strategies and public health initiatives.
What to keep in mind
The analysis relied on simulated effect sizes due to the unavailability of raw data from the included studies.