Sex differences in computed tomography-derived fractional flow reserve-guided management of stable coronary artery disease: a subgroup analysis of the TARGET trial.
EuroInterventionSep 7, 2026 (epub)
Clinical ResearchCardiology
Yipu Ding, Zinuan Liu, Dongkai Shan et al.
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In 30 seconds
This post hoc analysis of the TARGET trial examined sex differences in treatment outcomes for 1,216 patients with stable coronary artery disease (CAD) receiving either CT-FFR-guided care or standard care. The study found that CT-FFR guidance significantly reduced major adverse cardiovascular events (MACE) in females (HR 0.48) over two years, while no significant difference was observed in males.
Key findings
- CT-FFR-guided care reduced unnecessary ICA in males but not in females.
- Females in the CT-FFR group had a significantly lower MACE rate (HR 0.48) compared to standard care.
- Males showed no significant difference in MACE rates between CT-FFR and standard care (HR 0.89).
Why it matters
Understanding sex-based differences in treatment outcomes can help clinicians tailor management strategies for patients with stable CAD, potentially improving care and reducing adverse events, particularly in female patients.