Primary pulmonary salivary gland-type tumors in cytopathology practice: A systematic review and meta-analysis.
Cancer CytopatholSep 9, 2026
Henri Lagerstam, David Kalfert, Ivana Kholová
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of cytologic diagnoses of primary pulmonary salivary gland-type tumors (PSGTs) in 106 patients across 49 studies. The study found a cytohistologic concordance of 48.1%, with fine-needle aspiration showing the highest sensitivity at 75.0%, indicating its potential for improved preoperative assessment.
Key findings
- Cytohistologic concordance was 48.1% across the studies reviewed.
- Fine-needle aspiration had the highest sensitivity at 75.0%.
- Adenoid cystic carcinoma was the most common subtype, with 67 cases identified.
- Bronchial brushing and washing had lower sensitivities of 34.2% and 38.1%, respectively.
Why it matters
Understanding the diagnostic challenges and effectiveness of cytologic techniques for PSGTs is crucial for clinicians, as accurate preoperative assessment can significantly impact treatment planning and patient outcomes.